• 中国科技核心期刊
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  • 中国科技论文统计源期刊
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2019 Vol. 31, Issue 3

Launched:February 1989

Editor-in-Chief:PEI Jian-ming

ISSN:1009-7236

CN:61-1268/R

Supervisor: Fourth Military Medical University

Sponsor: Medical Informatics Association Shaanxi Provincial Association for Physiological Sciences

Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).
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2019, 31(3): 1-4.??
[Abstract](229) [FullText HTML](251) [PDF 657KB](14)
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Role of retinoic acid-associated orphan nuclear receptor alpha in myocardial injury in septic mice
Shi-chao HAN, Huan ZHAO, Yong-qiang XU, Zhen-zhen LI, Da-hai HU
2019, 31(3): 249-253.?? doi: 10.12125/j.chj.201902030
[Abstract](357) [FullText HTML](250) [PDF 989KB](10)
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AIM To investigate the role of retinoic acid-related orphan nuclear receptor alpha (RORα) in inflammatory responses and cardiac function injury to sepsis. METHODS A mouse model of sepsis was established by intraperitoneal injection of lipopolysaccharide (LPS). Macrophage was stimulated by LPS to establish a septic cell model. Cell transfection and mouse tail vein injections of over-expression plasmids were used to over-express RORα in cells and tissues and to explore the role of RORα in inflammatory responses and myocardial damage mediated by sepsis. The changes of RORα, NF-κB p65 and inflammatory cytokines were detected by real-time quantitative PCR and Western blot. The changes of cardiac function in mice with sepsis were detected by enzyme-linked immunosorbent assay and pathological section RESULTS RORα significantly decreased in LPS-stimulated macrophages (P < 0.05). Over-expression of RORα significantly inhibited the expression of inflammatory cytokines IL-1β and TNF-α in LPS-stimulated macrophages (P < 0.05). Over-expression of RORα significantly inhibited LPS stimulated nuclear translocation of NF-κB p65 in macrophages (P < 0.05). Over-expression of RORα in vivo significantly inhibited the release of inflammatory factors IL-1β and TNF-α in the serum of septic mice, reduced the content of myocardial enzymes LDH and CK-MB in septic mice and improved myocardial pathological damage mediated by sepsis. CONCLUSION RORα can inhibit the inflammatory response of macrophages by inhibiting the nuclear translocation of NF-κB p65, thereby alleviating the inflammatory response and myocardial injury in mice with sepsis.
Effect of κ-opioid receptor activation on myocardial damage caused by diabetes mellitus
Xiao-ming GU, Rui SHI, le-jin LUO, Hao-ran GUO, Rui AN, Zhen-hua LIU, Yuan-bo WANG, Na FENG, Min JIA, Juan LI, Jun NIU, Shu-miao ZHANG
2019, 31(3): 254-259.?? doi: 10.12125/j.chj.20180405
[Abstract](260) [FullText HTML](211) [PDF 911KB](4)
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AIM To study the effects of κ-opioid receptors on myocardial damage mediated by diabetic mellitus and its underlying mechanism. METHODS C57BL/6J mice were randomly divided into three groups: a control(Con) group, a diabetic mellitus (DM) group, and DM+U50, 488H (a κ-opioid receptor selective agonist) group. Diabetic mellitus models were established by intraperitoneal injection of streptozotocin (150 mg/kg) and a high fat diet for 7 weeks. Mice in the DM + U50, 488H group were treated with U50, 488H (1.5 mg/kg, i.i) for 1 wk. General physical signs were recorded during the experiment. Fasting blood glucose (FBG) was measured by glucometer and serum insulin was detected by kit. The structure and function of the heart were measured by echocardiography. Myocardial apoptosis was detected by a TUNEL kit and indexes of oxidative stress were measured by Elisa kit. RESULTS Compared with the Con group, FBG was increased (P < 0.01), wheras serum insulin was decreased significantly (P < 0.01). MDA activity in serum and myocardium were increased (P < 0.01). Total antioxidants content (T-AOC), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH) activity (or content) were decreased significantly (P < 0.01). There was an increased myocardial apoptosis (P < 0.01) and a decreased cardiac function in the DM group (P < 0.01). After treatment with U50, 488H, the above effects were abrogated (P < 0.01), which was accompanied by a decreased myocardial apoptosis (P < 0.01) and an increased cardiac function in the DM+U50, 488H group (P < 0.01). CONCLUSION κ-opioid receptor activation ameliorates myocardial damage caused by diabetic mellitus and further study is needed to demonstrate whether the role of κ-opioid receptor activation is mediated or modulated by inhibiting oxidative stress and improving activity of antioxidants.
Protective effect of hydrotherapy against chronic stress induced myocardial injury
Pei TIAN, Li XU, Hua-ning WANG, Peng-li WANG, Hong-yan YANG, Wen-dong HU, Wen-juan XING, Feng GAO
2019, 31(3): 260-265.?? doi: 10.12125/j.chj.201810034
[Abstract](248) [FullText HTML](203) [PDF 1020KB](4)
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AIM To observe the protective effect of hot water bath (hydrotherapy) on stress induced myocardial injury. METHODS Eighteen adult male Sprague-Dawley rats were randomly divided into control group, stress group and post-stress hot water bath intervention group (water bath group). Rats in the stress group and the water bath (WB) group were subjected to a 4-weeks foot electric shock combined with noise (4 h/d) and the rats in the WB group were given hot bath intervention (38-40 ℃). Body weight, blood pressure and cardiac functions were measured during the experiment and serum stress hormones and myocardial enzymes were measured after 4 weeks. Myocardial protein was determined by immunofluorescence and Western Blot, and the structure of myocardial mitochondria was observed by electron microscope. RESULTS The concentrations of NE and AngII in the serum of rats in the stress group were higher than those in the control group (P<0.05) and the levels of CK and LDH in the stress group increased (P<0.05). Further, compared with those in the control group, the positive staining of microtubule-associated protein 1 light chain 3B (LC3B) and the expressions of LC3II/I, p62 and Beclin1 in myocardial tissue in the stress group increased (P<0.05). Mitochondria showed decreased number and structural disorder in the stress group. Importantly, the hot water bath intervention decreased serum NE, Ang II concentrations and CK and LDH levels compared with those in the stress group (P<0.05). In addition, hot water bath significantly decreased p62 and Beclin1 expression levels (P<0.05) and reversed the mitochondrial structural damage. CONCLUSION Hot water bath reduce myocardial autophagy, improves mitochondrial structure and alleviates chronic stress induced myocardial injury where the mechanisms need further studies.
Effects of morroniside on expression of angiopoietin-1 and fibroblast growth factor-2 in infarcted myocardium in rats with acute myocardial infarction
Tian-bo WANG, Jia-min CUI, Ting-ting LIU, Fang-ling SUN, Yi-ran TAO, Zheng WU, Wen WANG, Yun-feng XIA
2019, 31(3): 266-269.?? doi: 10.12125/j.chj.201902016
[Abstract](258) [FullText HTML](219) [PDF 625KB](3)
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AIM To observe the effects of morroniside on the expressions of angiopoietin 1 (Ang-1) and fibroblast growth factor 2 (FGF-2) in the infarcted myocardium of rats with acute myocardial infarction. METHODS Twenty male Sprague-Dawley rats weighing 260-280g were selected and an AMI rat model was prepared by ligation of the left anterior descending coronary artery. The rats after successful modeling were randomly divided into a sham operation group, a model group, a low dose group of morroniside (45 mg/kg), a middle dose group of morroniside (90 mg/kg), and a high dose group of morroniside (180 mg/kg). From the first day after modeling, the rats were given morroniside regularly by gavage, and the sham operation and model groups were given the same amount of distilled water. The model rats were sacrificed 7 days after continuous administration and the protein expression levels of Ang-1 and FGF-2 in the infarcted myocardium were detected by Western blot. RESULTS Compared with those in the sham operation group, the protein expression of Ang-1 in the model group was significantly increased (P < 0.01), while the expression of FGF-2 showed an increasing tendency, but there was no significant difference (P>0.05). Compared with those in the model group, the expression levels of both Ang-1 and FGF-2 in the high dose group of morroniside were significantly increased (P < 0.01, P < 0.05). CONCLUSION Moroniside can up-regulate the expression of Ang-1 and FGF-2 in the infarcted myocardium of rats with acute myocardial infarction and promote angiogenesis.
Impact of restenosis pattern on clinical outcomes after simple paclitaxel-coated balloon angioplasty for in-stent restenosis
Long-xiang DENG, Fang-jun MOU, Yi LIU, Qi LIU, Wang-wei YANG, Lin-ying XIA, Qi SUN, Ling TAO, Ming YUAN
2019, 31(3): 270-273.?? doi: 10.1212/j.chj.201811017
[Abstract](269) [FullText HTML](215) [PDF 677KB](5)
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AIM To discuss the relationship between the pattern of in-stent restenosis (ISR) and clinical prognosis in patients treated with a Paclitaxel-coated Balloon (PCB). METHODS 246 patients with one target lesions were screened from 283 patients who underwent coronary angiography. These patients were diagnosed with ISR and treated with PCB. The 246 patients were divided into a focal lesion group (n = 101) and a non-focal lesion group (n = 145). The primary end point was target lesion revasculation (TLR) at 12 months. Secondary end points were 12-month major adverse cadiac events (MACE) (e.g., cardiac death, myocardial infarction, and TLR), and target vessel revascularization, all-cause death, and stent thrombosis. RESULTS There was no significant difference in clinical baseline data between the two groups. The rate of compliance balloon in the non-focal group was higher than that in the focal group (P < 0.01) and the length was longer (P = 0.01). the diameter of the cutting was larger in the focal group than that in the non-focal group (P < 0.05). The diameter of PCB in the focal group was larger (P < 0.01), and the length was shorter (P < 0.01). The event-free survival analysis of these 246 patients showed that the survival rate of TLR-free events in the focal group (P < 0.05) and the survival rate without MACE events (P < 0.05) were superior to those in the non-focal group. CONCLUSION AfterAfter PCB angioplasty for ISR, the morphologic pattern of ISR is also an important predictor of outcomes. The use of PCB for in-stent restenosis is safe and effective.
Correlation of endothelial microparticles and severity and prognosis of acute myocardial infarction
Xin ZHANG, Jing ZHOU, Zong-qi ZHANG
2019, 31(3): 274-277.?? doi: 10.12125/j.chj.201901037
[Abstract](204) [FullText HTML](150) [PDF 628KB](2)
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AIM To study the role of endothelial microparticles (EMP) in evaluating acute myocardial infarction (AMI) lesion severity and predicting AMI prognosis. METHODS 90 AMI patients were divided into two groups according to GENESI scores: a mild coronary artery disease group (n = 48) and a severe lesion group (n=48). The patients were followed up for about 1 year and they were divided into two groups according to their prognosis: a group with good prognosis (n = 23) and a group with poor prognosis (with adverse cardiovascular events, n = 67). Plasma EMP levels (EMP defined as CD31+/CD146+) were detected using flow cytometry and the correlation between EMP and the severity and prognosis of coronary artery disease was analyzed using SPSS 17.0. RESULTS Significant differences in EMP levels, LVEF (left ventricular ejection fraction), and rate of no-reflow were found between the two groups. EMP, no reflow, and LVEF were independent factors related to the severity of coronary artery lesions. The follow-up for prognosis of AMI patients found lower LVEF, higher EMP values, high GENESI scores, more incidence of three-vessel lesions, and no-reflow in the group with unfavorable prognosis. Three-vessel lesions, EMP, GENESI scores and no-reflow were independent factors correlated with poor prognosis of AMI. CONCLUSION Plasma EMP levels can be used in AMI patients for evaluating the severity of coronary heart disease lesions and reperfusion condition, and for predicting long-term prognosis of AMI.
Unfractionated heparin and enoxaparin in thrombolysis of acute ST-segment elvation myocardial infarction
Jian-gang WANG, Xiao-kui ZHAO, Hui ZHANG, Zhi-ming ZHAO, Jing HE, Xiao-hui SUN, Li YANG, Yong ZOU, Yao WANG, Xiao-zhen XUE, Rong BAI
2019, 31(3): 278-281.?? doi: 10.12125/j.chj.201810044
[Abstract](195) [FullText HTML](180) [PDF 558KB](3)
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AIM To compare the differences of unfractionated heparin and enoxaparin treatment of acute ST-segment elevation myocardial infarction in reteplase. METHODS 70 patients with acute ST-segment elevation myocardial infarction were divided into groups of A and B, with 35 patients in each group. The reteplase was adopted for thrombolytic therapy for patients in both Group A and Group B. Patients in Group A were injected with 4000 U of unfractionated heparin through the intravenous injection before thrombolysis and then to maintain 12 U/(kg·h) intravenous infusion of 48 h, according to the APTT to adjust the dose of unfractionated heparin, 48 h gradually after the reduction to subcutaneous enoxaparin 40 mg 2 times daily, sequential treatment of 2-7 d or to referral. Patients in Group B were injected with 30 mg of enoxaparin through intravenous injection before the thrombolysis and then subcutaneous injection with 1 mg/kg of enoxaparin after 15 min, every 12 h, treatment 2-7 d or to referral. Comparison of clinical therapy effects of patients in the two groups was performed with statistical analysis conducted on complication probability and analysis on cost-effects. RESULTS At 60 min, the vessel repass rate of patients in Group A was 83%, that of patients in Group B was 57%; at 120 min, the vessel repass rates of patients in Group A and Group B were 100% and 91%, respectively. The vessel repass rate of patients in Group A were higher than that of Group B patients with statistical significance (P < 0.05). The vessel repass time of Group A patients was shorter than that of Group B patients with statistical significance (P < 0.05). The TnI and CK-MB peaks of Group A patients were statistically lower than that of Group B patients (P < 0.05). The total complication probability of Group A patients was statistically lower than Group B patients (P < 0.05). The cost-effect ratio of Group A was lower than Group B, with statistical significance (P < 0.05). CONCLUSION In therapy for acute ST-segment elevation myocardial infarction, if reteplase is selected for thrombolytic therapy, it is more convenient, economical, safer and has better therapeutic effects to adopt unfractionated heparin in sufficient dosage for 48 h and subsequent of use enoxaparin when compared with use of enoxaparin during the entire therapy process.
Correlation between monocyte to high density lipoprotein cholesterol ratio and the severity of coronary artery stenosis in patients with coronary heart disease and clinical significance
Yun-xia DUAN, Rong ZHOU, Jie HE
2019, 31(3): 282-285.?? doi: 10.12125/j.chj.201812007
[Abstract](280) [FullText HTML](198) [PDF 671KB](1)
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AIM To investigate the relationship between monocyte to high density lipoprotein cholesterol ratio (MHR) and severity of coronary artery stenosis in patients with coronary heart disease and its clinical significance. METHODS 407 patients who underwent coronary angiography from July 2017 to April 2018 in the second Hospital of Shanxi Medical University were divided into a coronary artery disease group (coronary artery stenosisd ≥ 50%, n = 306) and a control group (coronary artery stenosis < 50%, n = 101). The degree of coronary stenosis was expressed by Gensini score. The clinical data of the two groups were collected and compared. Multivariate Logisitic regression analysis was used to analyze factors affecting degree of coronary artery stenosis. Pearson correlation analysis was used to analyze the correlation between MHR and coronary Gensini score in patients with coronary heart disease and a ROC curve was used to analyze the value of MHR in the diagnosis of coronary heart disease. RESULTS The Gensini score, monocyte count, low density lipoprotein cholesterol, total cholesterol and triglyceride levels in the coronary heart disease group were higher than those in the control group (all P < 0.01) and the level of high density lipoprotein cholesterol was lower than that in the control group (P < 0.01). Multivariate Logisitic regression analysis showed that MHR was an independent factor affecting the degree of coronary artery stenosis (Wald χ2 = 10.397, P < 0.01). Pearson correlation analysis showed that there was a significant positive correlation between MHR and coronary Gensini score in patients with coronary heart disease (r = 0.672, P < 0.05). The area under MHR of ROC curve was 0.742 (95%CI: 0.693-0.792). When the MHR cut-off point was 0.35, the diagnostic efficiency reached highest, the sensitivity was 62.7%, the specificity was 77.2% and the accuracy was 73.5%. CONCLUSION MHR is an independent correlation factor of coronary stenosis and can be used as an important reference index for clinical diagnosis of coronary artery disease.
The research of time of bandage removal after coronary angiography through the radial artery
Ya-min ZHANG, Li-yuan LIU, Ai-yuan CHENG, Qiong WANG, Ming YUAN, Mai CHEN, Ling TAO, Ru-tao WANG, Zhi-yong YIN, Yi LIU, Qiu-peng LI, Yuan HE
2019, 31(3): 286-288.?? doi: 10.12125/j.chj.201812003
[Abstract](348) [FullText HTML](259) [PDF 528KB](4)
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AIM To study the time of bandage removal after coronary angiography through the radial artery. METHODS 300 patients were selected with coronary heart disease who underwent coronary angiography but without stent implantation were divided into three groups according to postoperative pressurized bandaging time: a 4 h group (100 patients), a 6 h group (100 patients), a 8 h group (100 patients). The present investigation observed incidence of complications, including puncture point bleeding, forearm hematoma, limb necrosis, skin blister formation, discomfort of patients, routine blood work, prothrombin time (PT) and activated partial thromboplastin time (APTT) changes. RESULTS There were no significant differences in routine blood, prothrombin times, and activated partial thromboplastin times between the three groups before operation. There were no significant differences in incidence of bleeding at 4 h, 6 h and 8 h punctures after operation. There were no significant differences in puncture point bleeding, forearm hematoma, limb necrosis or local skin blister formation between the three groups. The discomfort in group 4 h was significantly lower than that in the 6 h and 8 h groups. CONCLUSION Based on the results of this study, bandage removal at 4 h after coronary angiography through the radial artery was safe with no obvious bleeding in the puncture point.
Comparison of effects of different lipid-lowering regimens on oxidized low-density lipoprotein and its ratio after PCI
Xin-yu FENG, Shan-jie WANG, Yuan DONG, Dong-dong SUN, Zhi-jing ZHAO
2019, 31(3): 289-294.?? doi: 10.12125/j.chj.201810074
[Abstract](206) [FullText HTML](150) [PDF 607KB](2)
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AIM To evaluate clinical efficacy and safety of different lipid-lowering regimens in patients after percutaneous coronary intervention (PCI). METHODS From January 2018 to July 2018, 104 patients with PCI planned were selected as study subjects and were randomly divided into a 10 mg rosuvastatin treatment group (n = 35), a 20 mg rosuvastatin treatment group (n = 35), and a 10 mg rosuvastatin +10 mg ezetimibe combined treatment group (n = 34). The patients were followed up for six months. Serum lipids were measured before and after treatment and compliance rate and adverse drug reactions were compared between the three groups. RESULTS Levels of TC, LDL-C, oxLDL-C, oxLDL-C/TC, oxLDL-C/LDL-C and oxLDL-C/HDL-C were significantly lower than before in the three groups after treatment (P < 0.05). The extent of reduction of TC and LDL-C in the combined 10 mg rosuvastatin + ezetimibe group was significantly larger than those in the 10 mg rosuvastatin and 20 mg rosuvastatin groups (P < 0.05). The rate of attaining the standard of serum lipid in the combined 10 mg rosuvastatin +ezetimibe group was higher than those in the 10 mg rosuvastatin and 20 mg rosuvastatin groups, with statistically significant differences (P < 0.05). There was no statistically significant difference in the incidence of adverse reactions between the three groups (P < 0.05). CONCLUSION The administration of rosuvastatin or the combined administration of rosuvastatin and ezetimibe in patients after percutaneous coronary intervention is safe and achieves beneficial effects in regulation of lipids and antioxidants and in attaining the standard of serum lipids.
Differentiation electrocardiogram and echocardiographic characteristics of hypertension induced left ventricular hypertrophy and hypertrophic cardiomyopathy
Zhi-ling MA, Zhi-jing ZHAO, Chuang YE, Hai-xia HU, Li-wen LIU, Hong SHAO
2019, 31(3): 295-301.?? doi: 10.12125/j.chj.201807015
[Abstract](214) [FullText HTML](188) [PDF 581KB](1)
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AIM To compare the differences in parameters of 12 lead routine electrocardiogram (ECG) and echocardiography between patients with hypertrophic cardiomyopathy (HCM) and hypertension induced left ventricular hypertrophy (H-LVH). To evaluate the ECG in detecting patients with HCM and H-LVH. METHODS Healthy individuals and patients with H-LVH or HCM were enrolled (n=49 in each group). ECG parameters were analyzed, including P wave duration, QTC duration, QRS duration, abnormal Q wave, the amplitude of R wave and S wave. E/A ratio, left ventricular ejective fraction (LVEF), maximum left ventricular wall thickness (MLVWT), left atrial diameter, systole of the left and right left ventricle, diastolic phase of the left and right left ventricle, systolic phase of the left ventricle anterior and posterior diameter, diastolic phase of the left ventricle anterior and posterior diameter, systole of the long axis of the left ventricle, diastolic phase of the long axis of the left ventricle were measured by conventional echocardiography. The above parameters were compared between groups. RESULTS Compared with the H-LVH group, patients with HCM presented with increased LVEF and MLVWT (P < 0.05). However, Per stroke output, systole of the left and right left ventricle, diastolic phase of the left and right left ventricle, systolic phase of the left ventricle anterior and posterior diameter, diastolic phase of the left ventricle anterior and posterior diameter, systole of the long axis of the left ventricle, diastolic phase of the long axis of left ventricle of H-LVH group were significantly higher in patients with H-LVH than patients with HCM (P < 0.05). CONCLUSION Compared with patients with H-LVH, patients with HCM had a higher QRS voltages in leads II, III, aVF, V1 and V2 and prolonged QTC duration(P < 0.01). The abnormal Q wave proportion and QRS main wave direction were consistent with T waves in lead III and aVR was higher in the HCM group.
Effects of dexmedetomidine combined with limb remote ischemic preconditioning on myocardial ischemia-reperfusion injury
Kai-kai XUE, Ling YANG, Hai-ming CHEN
2019, 31(3): 302-305.?? doi: 10.12125/j.chj.201811016
[Abstract](180) [FullText HTML](161) [PDF 557KB](5)
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AIM To study the effects of dexmedetomidine combined with remote ischemic preconditioning on myocardial ischemia reperfusion injury and to evaluate its effect on apoptosis. METHODS Eighty patients scheduled for heart valve replacement under cardiopulmonary bypass were randomly divided into 4 groups (n = 20): a control group (group C), a limb ischemia preconditioning group (group R), a dexmedetomidine pretreatment group (group D), and a dexmedetomidine pretreatment combined with limb ischemia preconditioning group (group DR). Group R received upper limb ischemic preconditioning after induction of anesthesia. In group D, dexmedetomidine was intravenously administered as a loading dose of 11 μg/kg for 10 min and then intravenously 0.41 μg/(kg·h) until the completion of the operation. Plasma troponin I (cTnI) levels were measured before aortic occlusion (T0), at the end of cardiopulmonary bypass (T1) and after the operation (T2). The contents of Bcl-2 and Bax protein and cardiomyocyte apoptosis index (AI) were measured before aortic occlusion and at the end of cardiopulmonary bypass. RESULTS Compared with group C, at T1 and T2, plasma cTnI decreased in all the other groups (P < 0. 05). Compared with those before aortic clamping, Bcl-2, Bax protein content and AI in the cardiac tissues of the four groups increased, and Bcl-2/Bax decreased after CPB (P < 0.05). Compared with those in group C, the protein of Bcl-2 and Bcl-2/Bax increased and the protein of Bax and AI decreased in group D, group R and group DR (P < 0.05). Compared with those in group R and D, the content of Bcl-2 and Bcl-2/Bax protein in the DR group increased and the value of Bax protein and AI decreased (P < 0.05). CONCLUSION Dexmedetomidine and limb remote ischemic preconditioning reduce myocardial ischemia reperfusion injury and the combined effects of the two are superior when compared to individual results. Inhibition of cell apoptosis is likely mechanisticly involved.
Factors affecting smoking cessation in patients with cardiovascular disease
Yun-shuang HOU, Shi-yi CHEN, Yue-chao ZHAO, Fei SUN
2019, 31(3): 306-308.?? doi: 10.12125/j.chj.201812040
[Abstract](157) [FullText HTML](157) [PDF 518KB](5)
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AIM To evaluate the impact of related factors on smoking cessation in patients with cardiovascular disease. METHODS Patients receiving health education for smoking cessation were followed up for 12 months and divided into an effective group (n = 156) and an ineffective group (n = 188) according to smoking cessation results. Each group was assessed on the effects of related factors on smoking cessation. RESULTS The rate of successful smoking cessation was higher in older patients (e.g., older than 70 years) patients with coronary artery disease, hypertension, heart failure, or less smoking (≤10 cigarettes/day)(all P < 0.01) and was lower in patients living in solitude or in close contact with smokers (both P < 0.01) during the follow-up period. Logistic multi-factor regression analysis showed that coronary artery disease, heart failure, less smoking, smoking exposure and living state were independent factors influencing rate of successful smoking cessation. Coronary heart disease, heart failure, and less smoking improved and living alone and smoking exposure reduced efficiency of smoking cessation. CONCLUSION Severe illness can improve the efficiency of smoking cessation; however, living alone and contacting smokers did not improve efficiency of smoking cessation.
Comparison of magnetocardiography parameters in patients with lesions in different coronary arteries
Xiao HUANG, Ning HUA, Wei-hua ZHANG, Fa-kuan TANG
2019, 31(3): 309-311.?? doi: 10.12125/j.chj.201808019
[Abstract](173) [FullText HTML](138) [PDF 508KB](2)
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AIM To investigate the change of magnetocardiography (MCG) parameters in patients with lesions in different coronary arteries. METHODS 99 CHD patients with monovascular lesion were recruited to test the diagnostic accuracy of 10 MCG parameters (Map angle on T peak, TT_Map angle maximum, TT_Map angle minimum, TT_Map angle dynamics, TT_Distance dynamics, Maximum-to-minimum ratio on T peak, Current angle at T peak, TT_Current angle maximum, TT_Current angle minimum and TT_Current angle dynamics), with 91 non-CHD patients serving as a control group. CHD Patients were divided into a LAD group (n = 44), a LCX group (n = 25), and a RCA group (n=30). RESULTS Compared to the control group, Map angle on T peak was significantly higher in the LAD group (P < 0.05) and the LCX group (P < 0.01). TT_Map angle maximum and TT_Map angle dynamics were also higher in the LCX group, compared to the control group (all P < 0.01). In the RCA group, TT_Map angle minimum and TT_Distance dynamics were significantly lower (all P < 0.01), whereas TT_Current angle maximum and TT_Current angle dynamics were higher (all P < 0.01), compared to the control group. Map angle on T peak was significantly lower in the LAD group and the RCA group, compared with the LCX group (respectively, P < 0.01, P < 0.05). TT_Distance dynamics was lower in the RCA group, compared to the LAD group (P < 0.01). CONCLUSION There were numerous parameters altered in patients with lesions in different coronary arteries.
Surgical treatment of late tricuspid regurgitation after left cardiac valve replacement
Yu-chen ZHAO, Bin CUI, Dong-hui XU, feng Lü
2019, 31(3): 312-314.?? doi: 10.12125/j.chj.201808053
[Abstract](176) [FullText HTML](159) [PDF 531KB](4)
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AIM To investigate postoperative results of late tricuspid regurgitation (TR) after left cardiac valve replacement. METHODS The present investigation retrospectively reviewed 42 patients with a history of left-sided valve operations who underwent tricuspid procedures from Jan 2007 to Jan 2017. RESULTS The mean age of the 42 patients (e.g., 11 men and 31 women) was 52±11 years with an age range of 30 to 66 years. The mean time from last surgery was 11±4 years with a range of 1 to 19 years. Mitral perivalvular leakage or aortic perivalvular leakage was found in 24 patients. Surgical technique included tricuspid valve repair in 31 patients, while 11 patients underwent tricuspid valve replacement (e.g., 3 bioprosthetic valve prostheses, 8 mechanical valve prostheses). The early mortality rate was 14% (6 of 42 patients; 2 repairs, 4 replacements). Follow-up was complete in 37 patients (88%) with a median follow-up of 73±31 months (IQR 6~120 months). Amongst patients who underwent tricuspid valve repair, 22 had none-to-mild tricuspid regurgitation and 4 had moderate-to-severe tricuspid regurgitation. CONCLUSION Tricuspid valve procedures after left-sided valve operations in rheumatic patients can have good clinical outcomes. The management of left ventricular dysfunction before the operation plays an important role in the entire process. Proper selection of surgery is critical for success.
Short-term simulated weightlessness causes abnormal expression of rat circadian clock gene
Dong DONG, Li CHEN, Bin ZHANG, Lin YU, Jin MA, Man-jiang XIE
2019, 31(3): 315-319.?? doi: 10.12125/j.chj.201902038
[Abstract](184) [FullText HTML](165) [PDF 913KB](2)
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AIM To evaluate the effects of one-week simulated microgravity on the expression of circadian rhythm in rats. METHODS The tail suspension hindlimb unloading model was used to simulate a space microgravity environment. 48 male SD rats (aged 8 weeks) were randomly assigned to a control (CON) and a tail suspension (SUS) group (24 each). Rats in both groups were housed under the same light conditions (8:00-20:00). Western blotting was used to detect the expression levels of clock genes (Per2, Bmal1) and ion channels Cav1.2 protein in the suprachiasmatic nucleus (SCN) of rats at different time points. Real-time quantitative PCR was used to detect the transcription levels of Per2 and Bmal1 in SCN at different time points. RESULTS Short-term simulated weightlessness caused a decrease in the transcription and protein expression of clock genes Per2 and Bmal1 in rat SCN (P < 0.05) and the fluctuation amplitude was significantly reduced. In addition, compared with that in the control group, simulated weightlessness caused a significant increase in Cav1.2 protein expression in SCN of SUS rats. CONCLUSION Short-term simulated weightlessness can cause abnormal expression of rat clock genes, which may be one of the mechanisms that simulate pathological changes of the body caused by weightlessness. This finding provides direct evidence for the direct conversion of gravity-changing signals into time-ratio signals.
Relationship of homocysteine and essential hypertension in civil aviation pilots
Zhi-min WANG, Jian-zhi WANG, Ning NI
2019, 31(3): 320-322.?? doi: 10.12125/j.chj.201807043
[Abstract](209) [FullText HTML](155) [PDF 522KB](3)
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AIM To study levels of homocysteine and blood lipids in patients with essential hypertension. To investigate the relationship between homocysteine and hypertension. To analyze the correlation between serum lipids and homocysteine. METHODS 28 healthy patients were placed in a control group and 38 hypertensive patients were placed in a hypertension group. The hypertension group was divided into a lipid- regulating therapy group (20 cases) and a non-lipid-regulating therapy group (18 cases). Homocysteine, total cholesterol, low density lipoprotein, apolipoprotein B were measured. RESULTS Compared with the control group, homocysteine levels in the hypertension group increased significantly (P < 0.05). Compared with the non-lipid-regulating group, total cholesterol, low densitylipoprotein and apolipoprotein B were significantly decreased (P < 0.05); however, homocysteine levels were not significantly decreased in the lipid regulating group; Correlation analysis of Pearson showed that homocysteine was not related to the blood lipid index in the lipid regulating group. CONCLUSION Hyperhomocysteinemia is a risk factor in essential hypertension. Homocysteine is not correlated with total cholesterol and low-density lipoprotein. Lipid-regulating therapy does not improve plasma homocysteine levels.
Application of mind map in teaching aeromedical evaluation of hypertension
Bin WANG, Han WANG, Bai RUAN, Tao CHEN, Jing XING, Feng-tao XING, Jun-hui XUE
2019, 31(3): 323-326.?? doi: 10.12125/j.chj.201901045
[Abstract](222) [FullText HTML](166) [PDF 644KB](3)
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A mind map shows the advantage of high efficiency on information processing in many specific areas. In the aeromedical evaluation of hypertension, there is a lack of valuable tools to process the involved information. By analyzing the principles of a mind map and features of aeromedical evaluation of hypertension, this review discusses the practical application value of a mind map on the teaching of aeromedical evaluation.
Research progress in potassium channel and arrhythmia induced by obesity
Wei SHUAI, He HUANG
2019, 31(3): 327-330.?? doi: 10.12125/j.chj.201807016
[Abstract](240) [FullText HTML](222) [PDF 525KB](7)
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Obesity predisposes to arrhythmia and treatment is limited. Existing evidence suggests that obesity-induced arrhythmia is associated with abnormal cardiac potassium channels. The study of cardiac potassium channel expression and electrophysiological mechanism in obese patients should improve understanding of obesity-induced arrhythmia, potentially discover new pathological mechanisms, and identify potentially new therapeutic targets. Given the worldwide epidemic of obesity, this information could be highly beneficial for obese patients. This article, therefore, reviews research progress of cardiac potassium channels and arrhythmia induced by obesity.
Phrenic nerve paralysis during perioperation in cryoballoon ablation for atrial fibrillation
Ying CHENG, Jia-bo JI, Fu YI, Yuan-yuan CHENG, Lei ZHANG
2019, 31(3): 331-333.?? doi: 10.12125/j.chj.201801048
[Abstract](384) [FullText HTML](249) [PDF 569KB](5)
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Cryoballoon ablation for paroxysmal atrial fibrillation (AF) has been recommended as a first-line treatment by 2016 ESC Guidelines for the management of atrial fibrillation and its effectiveness and safety has been previously demonstrated. Compared with radiofrequency ablation, cryoballoon ablation possesses the characteristics of briefer learning curve, shorter operation time, and less patient suffering. As a result, cryoballoon ablation is widely accepted in clinical treatment. However, phernic nerve paralysis, the most common complication, should be well understood to minimize occurence. In this review, we present a systematic investigation of phernic nerve paralysis caused by cryoballoon ablation for paroxysmal atrial fibrillation.
Role and research progress of NLRP3 inflammasome in cardiomyopathy and arrhythmias
Wei LI, Ming-xin LIU, Yan-hong TANG
2019, 31(3): 334-338.?? doi: 10.12125/j.chj.201809038
[Abstract](272) [FullText HTML](231) [PDF 571KB](4)
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NLRP3 inflammasome is a participant in the innate immune response that triggers inflammation through a related activation signal. NLRP3 inflammasome is expressed in cardiomyocytes and cardiac fibroblasts, and caspase-1 is generated by procaspase-1 hydrolyzed to promote the maturation and release of IL-1β and IL-18, resulting in cell pyroptosis. Its infiltration affects the development of cardiovascular diseases such as cardiomyopathy and arrhythmia. In this review, we describe the role and related mechanisms of NLRP3 inflammasomes in cardiomyopathy and arrhythmias, which are important in exploring treatment options for NLRP3 inflammasome related diseases.
Research progress in relationship between prostaglandin E2 and cardiovascular diseases
Te SHI, Xing TAN, Wei-zhong WANG, Yang-kai WANG
2019, 31(3): 339-342.?? doi: 10.12125/j.chj.201810012
[Abstract](226) [FullText HTML](197) [PDF 560KB](7)
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Prostaglandin E2 (PGE2), an extremely important arachidonic acid metabolite in the body, is released when stimulated by various physiological or pathological stimuli and mediates inflammatory response, regulates blood pressure, and is involved with other biological effects through specific receptors. There are four kinds of specific receptor subtypes (E-prostanoidreceptors, EP1, EP2, EP3 and EP4) in the body which mediate the effects of PGE2. However, given the antagonistic effects mediated by these four subtypes, PGE2 has a complex effect on the cardiovascular system, which is usually determined by receptor subtype in specific organs or tissues. This review summarizes the latest research related to PGE2 in cardiovascular diseases, includiong atherosclerosis, thrombosis, hypertension, and stroke from the perspective of receptor action characteristics, aiming to provide new ideas in PGE2 role in cardiovascular pathogenesis.
Role of calcium sensing receptors in cardiovascular physiology and disease
Chun-ming XIONG, Zhao-ying ZHANG
2019, 31(3): 343-346.?? doi: 10.12125/j.chj.201809003
[Abstract](299) [FullText HTML](267) [PDF 559KB](5)
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Calcium sensing receptor (CaSR), a member of the G protein coupled receptor (GPCRs) C family, can be activated by Ca2+ Mg2+, amino acids, and polyamines. It is now recognized as an ubiquitously expressed receptor and is highly expressed in the parathyroid gland, kidneys, intestinal system, and skeletal system. It also plays different roles in different tissues of the cardiovascular system and participates in physiological and pathological processes of the cardiovascular system. The focus of this review is to summarize the importance of CaSR in the cardiovascular system.
Application progress of two dimensional speckle tracking imaging in assessment of left atrial function
Xiao-yan FU, Rui-ling YAN, Si-yang ZUO, Xiao-ling ZHAO
2019, 31(3): 347-351.?? doi: 10.1212/j.chj.201807039
[Abstract](227) [FullText HTML](210) [PDF 557KB](2)
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Left atrial function has attracted significant attention clinically as it is an important indicator of many diseases. Early detection of left atrial dysfunction is of great importance for appropriate therapy and good prognosis. Two-dimensional speckle tracking imaging (2DSTI) is a new technology used to assess myocardium motion and it can detect myocardium dysfunction earlier than conventional echocardiography. This review focuses on the progress of 2DSTI used to assess left atrial functions.
Progress and prospect in transcatheter mitral valve repair treatment of heart failure caused by mitral valve regurgitation
Sheng-wei LAI, Deng-hui LU, Jian YANG
2019, 31(3): 352-357.?? doi: 10.1212/j.chj.201807036
[Abstract](280) [FullText HTML](238) [PDF 705KB](3)
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365bet娱乐场在线下载365bet靠谱么Mitral valve insufficiency is mainly caused by valve abnormality which gives rise to degenerative mitral regurgitation (MR)/primary MR and it also can be caused by secondary cardiomyopathy, which gives rise to functional MR/secondary MR. Though medical management can alleviate homologous symptoms, it cannot inhibit progression of the disease. Current guidelines recommend surgical treatment for moderate-to-severe (Grade > 3) MR in patients with symptoms or evidence of left ventricular dysfunction. However, related to many subjective and objective reasons, the majority of patients with severe MR are reluctant to choose surgery. Transcatheter mitral valve repair treatments have been developed and transcatheter mitral valve repair treatment mainly comes from a surgical repair technology. It is represented by means of edge to edge, artificial chords repair, and annuloplasty. Clinical applications of different kinds of instruments have achieved good results. Recently, the emergence of percutaneous interventional approaches in treating MR has offered new options for patients who are at high risk for conventional mitral valve (MV) surgery. In this article, we review the new advances of surgical treatments of heart failure caused from mitral regurgitation.
Research progress in pathogenesis of total anomalous pulmonary venous connection
Ting XU, Shi-wei YANG, Yu-ming QIN
2019, 31(3): 358-360.?? doi: 10.12125/j.chj.201810021
[Abstract](215) [FullText HTML](200) [PDF 514KB](4)
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Total anomalous pulmonary venous connection (TAPVC) is a rare and serious congenital heartdisease, in which none of the pulmonary veins connect to the left atrium and instead directly connectto the right atrium or the systemic venous system. The growth and development of children with TAPVCis significantly limited. TAPVC-induced cyanosis and tissue hypoxia is gradually worsened after birth, which seriously threatens the life of those affected. TAPVC is an absolute indication for surgical repair. However, itscauses and mechanisms are still unclear. In recent years, the development of modern moleculargenetics has led to a preliminary understanding of the pathogenesis of TAPVC. This article reviews research progress in the pathogenesis of TAPVC and clinical implications.
Mechanism of exercise for cardiovascular protection
Tian-ce WANG, Yao LI, Li-wen ZHU, Zheng-bin ZHANG, Bing ZHANG, Pan FENG, Yang SUN, Wei YI
2019, 31(3): 361-365.?? doi: 10.12125/j.chj.201810043
[Abstract](240) [FullText HTML](191) [PDF 580KB](3)
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Appropriate exercise can significantly reduce incidence and mortality of cardiovascular diseases and effectively improve prognosis of cardiovascular patients. Excercise has been regarded as effective in prevention and adjuvant treatment of cardiovascular diseases. Exercise has been shown to reduce inflammation, improve vascular endothelial function, regulate energy metabolism, and protect against myocardial damage. Nonetheless, the mechanisms mediating exercise-induced benefits for cardiovascular diseases are complex and many still remain to be elucidated. This review focuses on currently understood mechanisms related to exercise induced cardioprotection, with an emphasis on the important roles that insulin sensitization, endothelial cells, myocardial mitochondrial adaptations, and miRNAs play in producing the protected phenotype.
Investigation and preliminary study on teaching design of high altitude cardiopathy based on MOOC
Di-ya WANG, Wen-kai JIANG, Zi-yan YUAN, Fang ZHAO, Xue-feng SHEN, Wen-jing LUO
2019, 31(3): 366-368, 372.?? doi: 10.12125/j.chj.201903058
[Abstract](58) [FullText HTML](60) [PDF 513KB](1)
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AIM To evaluate concrete ways and methods of combining Massive Open Online Courses (MOOCs) with traditional teaching methods in the teaching process of high altitude cardiopathy. METHODS According to the different majors of 206 students in the spring semester of 2018, a questionnaire was designed to understand the cognition and demand of undergraduate students and to provide a basis for the subsequent curriculum arrangement of high altitude cardiopathy. RESULTS In the spring semester of 2018, only 17 students (8.5%) had a complete knowledge of MOOCs, 77 students (37.26%) had known about it, and 84 students (40.8%) had heard of it but did not know the way it was taught. 28 students never heard of MOOCs (13.44%). In addition, 33 students (15.81%) considered it very necessary to set up the MOOCs of high altitude cardiopathy courses, and 73 students (35.61%) considered it necessary to set up these courses. It is no concerned about 86 students (41.98%) whether if set up MOOCs or not. And only 14 people (6.6%) think that it is not necessary to set up high altitude cardiopathy MOOCs courses. A questionnaire was conducted to investigate the needs of high altitude cardiopathy courses for all students in the spring semester of 2018. CONCLUSION Undergraduates majoring in clinical medicine in military academies know less about the MOOCs. In order to ensure the smooth development of MOOCs of high altitude cardiopathy, it is necessary to increase media attention of MOOCs courses, so that they can become an extension of traditional teaching and be a greater part of young cadets’ education.
Application of 3D printing model in teaching of vascular-related diseases in urology
Bin SONG, Bo ZHANG
2019, 31(3): 369-372.?? doi: 10.12125/j.chj.201809060
[Abstract](221) [FullText HTML](179) [PDF 578KB](6)
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AIM To evaluate the application of 3D printing models in the teaching of urological vascular-related diseases (e.g., nutcracker syndrome, retrocaval ureter) and to explore its feasibility and effectiveness. METHODS The trainees were randomly divided into two groups, the traditional teaching method group (control group) and the teaching method using the 3D printing model group (experimental group). Theoretical and practical assessments were compared between the two groups and the satisfaction of the teaching mode combining 3D printing models was tested by questionnaire. RESULTS The examination results in the experimental group were better than those in the control group (P < 0.05). The results in the experimental group questionnaire survey on the satisfaction of the teaching mode showed that 96.67% of the students were satisfied with the overall evaluation of the teaching mode combining 3D printing model. CONCLUSION The application of 3D printing models in the teaching of urological vascular-related diseases can visually demonstrate the disease model, which helps to deepen students’ understanding and memory of relevant knowledge and improves teaching quality. The application of 3D printing model is an effective teaching method.
Case report: Complex and high risk indicated patient undergoing PCI complicated with cerebral infarction
Ru-tao WANG, Xu-yang FENG, ji Sumitsu, Qiong WANG, Ling TAO
2019, 31(3): 373-374.?? doi: 10.12125/j.chj.201805031
[Abstract](202) [FullText HTML](199) [PDF 592KB](9)
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